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The researchers defined 16 GLP-1RA treatment scenarios for GLP-1RA users by semi-annually reassigning their treatment status, conditional on their current use status, thereby emulating dynamic treatment strategies over time
The trial also compared continuation at 2.4 mg with a placebo switch
The odds for semaglutide discontinuation also increased for adults with a higher Charlson comorbidity index, with those having an index score of 3 or higher being the most likely to stop using semaglutide (RR = 1.09
This is higher than what the numbers showed for the injection and the reason is SNAC
Understanding semaglutide withdrawal symptoms helps set expectations for what the discontinuation period feels like and how to manage the transition